Real Whole-Body MRI: Requirements, Indications, Perspectives
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Goyen, M. Citation Export Print Permalink Translate. Abstract Abstract. The editor and authors have made crucial contributions towards establishing whole-body MRI in various investigative settings, rendering it more precise and applying it for diverse indications. The work presented here is founded upon the extensive experience of the editor, as well as drawing upon the broad range of experience from other scientific working groups.
The first section of the book is dedicated to the technical requirements of whole-body MRI, as well as the principles and the associated data processing, whereas all aspects of whole-body MRI are presented from a clinical perspective in the subsequent chapters. This includes examination techniques, an update of the clinical questions posed, and a richly illustrated presentation of the clinical areas of cardiovascular investigation and musculoskeletal diseases.
Oncological whole-body imaging tackles the comparison of whole-body MRI with bone scintigraphy in the detection of bone metastases, and with FDG-PET in respect to whole-body tumor staging. Both the clinical and experimental questions concerning whole-body MRI are addressed in detail. Country of publication. Descriptors DEI. Descriptors DEC.
- Real Whole Body Mri Requirements Indications Perspectives By Mathias Goyen.
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Close Proceed. The cause is unknown, however, it might be a marker of physical trauma, infection, or tumor as well. There are approximately 26 million cases of hydrocele worldwide. These small majority of lesions measure from 0. Due to atherosclerosis as the number one in morbidity and mortality in developed countries and its high prevalence, there is an increasing need to detect the most threatening manifestations of vascular disease well in advance.
The asymmetry of the VAs might be due to hypoplasia which is very common and can be identified on MRI, its prevalence is unknown. WB-MRI can be performed by the application of various sequences.
Magnetic resonance imaging
T1-weighted images after contrast agent application can depict lesions in parenchymal organs and bone and soft tissues due to higher spatial resolution. Advantage of adding a DWI sequence to this study has the depiction of areas of restricted diffusion which allows the better visualization of areas of high cellularity, i.
The ideal screening technique must be both sensitive and specific, widely available, cost-effective, reader independent, and without harmful side effects. The diagnostic test must be standardized implying a low number of false results. MR is likely to meet these criteria especially in diseases which are ideal for screening, including colorectal cancer and cardiovascular disease, as demonstrated with examples in our study.
The incidental findings were mainly related to the fields of urology, rheumatology and internal medicine in almost two-thirds of the cases. The corresponding screening costs are also determined by these indirect costs related to these subsequent and follow-up tests beyond the direct costs of the screening test itself.
The strengths of our study include the highly selected patient group, the advantages of high field 3-T wide bore magnet system and the use of whole-body DWI acquisitions. Second, the investigated healthy adults represent a small proportion of the population at risk, and the prevalence of malignancies and cardiovascular atherosclerotic lesions are likely to occur in the higher-risk group with lower socioeconomic status.
Therefore, these are individuals who are likely to undergo WB-MRI scans in the near future due to financial reasons, and our findings are highly relevant in this context. However, the present study also has some limitations. The major limitation of our study is the relatively low number of subjects, although it is comparable to other previous investigations. In conclusion, our data suggest that 3 T wide bore WB-MRI, DWI and MRA of high diagnostic accuracy lead to the detection of clinically relevant diseases and many incidental findings in a cohort of healthy adults that require further imaging or surveillance in two-third of subjects.
Furthermore, research involving large numbers of patients is required to determine the potential benefit or burden of communicating incidental findings to study volunteers. Disclosure: No potential conflicts of interest were disclosed. National Center for Biotechnology Information , U. Journal List Radiol Oncol v.
Radiol Oncol. Published online Mar 3. Author information Article notes Copyright and License information Disclaimer. Correspondence to: David Laszlo Tarnoki, M. E-mail: moc.
Myth: Whole-body screening is an effective way to detect hidden cancers
Received Dec 12; Accepted Jun This article has been cited by other articles in PMC. Results A suspicious pararectal malignancy was detected in one patient which was confirmed by an endorectal sonography. Keywords: angiography, incidentaloma, atherosclerosis, high field magnet, diffusion weighted imaging. Introduction Whole-body magnetic resonance imaging WB-MRI has become increasingly popular in the recent decade due to its high soft tissue spatial resolution, multiplanarity, lack of ionising radiation, low incidence of nephrotoxicity caused by contrast agents, as well as high sensitivity and specificity in the detection of vascular and malignant diseases.
Open in a separate window. Discussion To the best of our knowledge, this is the first study to investigate the clinical value of whole-body MRI and MRA in a highly selected group of extremely health conscious general adult population on a 3-T basis using a wide bore magnet including WB-DWI acquisitions.
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TABLE 1. Spatial resolution data of our study acquisitions. Acknowledgments BBraun Medical Ltd. Footnotes Disclosure: No potential conflicts of interest were disclosed.
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References 1. Perspectives for preventive screening with total body MRI.
Eur Radiol. Whole-body MR angiography using a novel receiving-channel magnetic resonance MR system with surface coil technology: first clinical experience. J Magn Reson Imaging. The burden of cardiovascular diseases mortality in Europe. Eur Heart J. Ladd SC. Whole-body MRI as a screening tool? Eur J Radiol. Potentially relevant incidental findings on research whole-body MRI in the general adult population: frequencies and management. Prevention without radiation - a strategy for comprehensive early detection using magnetic resonance tomography. Baumgart D, Egelhof T.
Preventive whole-body screening encompassing modern imaging using magnetic resonance tomography. Full-body cardiovascular and tumor MRI for early detection of disease: feasibility and initial experience in subjects. Cardiovascular screening with parallel imaging techniques and a whole-body MR imaging. The prevalence and quantification of atherosclerosis in an elderly population assessed by whole-body magnetic resonance angiography.