The Origins of Health and Disease

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Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen. Am J Clin Nutr ; 82 5 —7. Developmental plasticity and human health. Nature ; — Developmental origins of health and disease: a paradigm for understanding disease etiology and prevention. Curr Opin Pediatr ; 27 2 — Maternal smoking during pregnancy predicts adult offspring cardiovascular risk factors—evidence from a community-based large birth cohort study.

PLoS One ; 7 7 :e Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest ; 10 — Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 b-hydroxysteroid dehydrogenase inhibitor carbenoxolone.

Diabetologia ; 39 11 — Prenatal hypoxia independent of undernutrition promotes molecular markers of insulin resistance in adult offspring. Programming of adult blood pressure by maternal protein restriction: role of nephrogenesis.

Developmental Origins of Health and Disease

Kidney Int ; 65 4 — Intrauterine programming of the endocrine pancreas. Diabetes, Obes Metab ; 9 s2 — Mechanisms underlying the developmental origins of disease. Rev Endocr Metab Disord ; 13 2 — Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet ; 33 3s — Persistent epigenetic differences associated with prenatal exposure to famine in humans.

Developmental Origins of Health and Disease | University of Helsinki

An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth. Clin Endocrinol Oxf ; 77 6 — Programming of adipose tissue miR—3p and GDF-3 expression by maternal diet in type 2 diabetes. Cell Death Differ ; 19 6 — Mutations in the glucokinase gene of the fetus result in reduced birth weight.

Nat Genet ; 19 3 — DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res ; 35 22 — The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk. J Endocrinol ; 1 :1— WHO Noncommunicable diseases; Moore SE. Early life nutritional programming of health and disease in the Gambia. J Dev Orig Health Dis ; 7 2 — WHO Global health risks; Developmental origins of health and disease: reducing the burden of chronic disease in the next generation.

Genome Med ; 2 2 WHO Preventing chronic diseases: a vital investment; Non-communicable diseases in low- and middle-income countries: context, determinants and health policy.


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